12/13/2023 0 Comments Charmas generalThese latter, in particular, are well-known for their healthy functions, including antioxidant, antimicrobial, antiproliferative, anti-inflammatory and neuroprotective properties therefore, the recovery of phenolic compounds from agro-industrial by-products is today a cutting-edge issue within the field of circular economic systems. Plant-based by-products are in general rich in functional compounds, including polysaccharides, vitamins, dietary fibers, oils, and phenolic compounds. To counteract this global issue, several strategies have been and are currently being pursued, among which is the valorization of agri-food wastes and by-products as sources of bioactive compounds to be used, e.g., as functional food ingredients or nutraceuticals. These results bring new opportunities for the valorization of fruit distillery by-products as low-cost resources for the design of bioactive formulations of comparable value to that from fresh food.Īccordingly to FAO estimation, 221 million tons of food are lost and wasted every year in the production and retail chains. Notably, the antiproliferative activity of the sample was comparable to that observed with an analogous extract prepared from unfermented, fresh strawberries. Moreover, at an early time (<30 min), reactive oxygen species (ROS) production and inactivation of the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinases (MAPK) pathway were detected. A strong decrease in viability in human promyelocytic leukemia (HL-60) cells through a rapid and massive apoptosis were observed. It was also able to induce an antiproliferative effect on different human cancer cell lines. ![]() The extract exhibited high antioxidant properties, particularly in the ferric reducing/antioxidant power (FRAP) assay, and a high total phenolic content (TPC). ![]() The main low molecular weight phenolic components of the extract were identified as ellagic acid and p-coumaric acid using spectroscopic and chromatographic analysis. We report herein the in vitro antioxidant and antiproliferative properties of an extract obtained from the waste of fermented strawberry distillate production. The production of fruit distillates generates solid residues which are potentially rich in bioactive compounds worthy of valorization and exploitation.
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